Author

Qiang Gao

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#protein folding Open access Sep 2026

Engineered genomic attachment sites for site-specific recombinases enable high-efficiency integration in plants and human cells.

Here we developed a DNA-centric strategy for optimizing site-specific recombination by rationally engineering chimeric attachment sites. The high-activity att variants enhance Bxb1-mediated integration efficiency in human cells and plants. Among these att variants, the engineered attB(V111) site achieved 51.9% integrat...

Lin-Li Yan, Ling Zhou, Qiang Gao et al. · Nature Biotechnology · 0 citations

Open access Aug 2026

Unraveling the Yield-Soil Amelioration Nexus in Alkaline Soils: Agronomic Performance and Soil Chemical Responses of Green Manure Crops

Although green manure crops are widely recognized for ameliorating alkaline soils, some previous studies have focused mainly on laboratory germination screenings or single yield indicators, and field validation of the synergy between high yield and soil improvement remains comparatively limited. This study evaluated 16...

Ruonan Du, Qiang Gao, Xue Yang et al. · Agronomy · 0 citations

#gene editing Aug 2026

Engineering RNA-guided bridge recombinases for precise large-scale genome editing.

An RNA-guided bridge recombinase system is engineered through rational mutagenesis and AI-assisted directed evolution, enabling programmable chromosomal rearrangements in both plant and mammalian cells and achieving up to a 29.8-fold increase in activity.

Rui Gao, Jingjing Wei, Chao Sun et al. · Trends in Biotechnology · 0 citations