Delivering the Undeliverable: Rational Engineering of Membrane-Based and Synthetic Nanoparticle Platforms
Delivering therapeutic macromolecules to defined cell populations in vivo remains a central unsolved problem in biomedicine. Proteins, nucleic acids and viral vectors are cleared by phagocytes, degraded by enzymes, blocked by endothelial and interstitial barriers, and trapped in acidifying endolysosomes. Pre-existing i...
Qiang-Bing Yang
· 0 citations