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Preethi H. Gunaratne

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#protein folding Open access Oct 2026

Food-Relevant Polycyclic Aromatic Hydrocarbons Disrupt Intestinal Barrier and Xenobiotic Metabolism in Mouse, Pig, and Human Epithelial Cells.

Because BaP may not fully account for the toxicity of all PAHs, this study provides relevant quantitative benchmarks for intestinal toxicity, advancing knowledge on current PAH exposure risk assessment.

Nedrick T. Distor, Manas Warke, Preethi H. Gunaratne et al. · 0 citations
Aug 2026

Combination of tart cherry and fish Oil exerted stronger attenuation of high-fat diet-induced gut dysbiosis and dysfunction in females than in males.

BACKGROUND Gut dysbiosis, disrupted intestinal barrier integrity, and elevated bacterial lipopolysaccharide levels are hallmarks of obesity-related metabolic dysfunctions. Fish oil (FO) and tart cherry (TC) have individually been shown to modulate gut microbiota dysbiosis and improve gut integrity. OBJECTIVE We hypot...

Maryam Seifishahpar, Jung Han Kim, Mostafa Abdelrahman et al. · 0 citations
Open access Sep 2026

Atlas-Guided Cell-Specific Transcriptomics Identifies Pathway-Level Remodeling of Human Hypothalamic CRH Neurons in Opioid Use Disorder

Opioid use disorder (OUD) disrupts hypothalamic stress signaling, yet the molecular state of human paraventricular nucleus (PVN) corticotropin-releasing hormone (CRH) neurons remains poorly defined. Using single-nucleus RNA sequencing of 343,819 human hypothalamic nuclei, we applied complementary human HYPOMAP/MapMyCel...

Lorna Barrall, Phillip Urbanczyk, Bruno Kluwe-Schiavon et al. · 0 citations
Aug 2026

Spatial biology reveals altered macrophage states in immunosuppressed non-melanoma skin cancer.

Overall immune-cell composition was largely preserved despite differences in immune-cell distribution, spatial organization, and T cell clonality, and multi-cohort validation across complementary spatial and single-cell platforms identified consistent alterations in innate-adaptive immune organization in immunosuppress...

Shorook Naara, V. Kochat, Xiayu Rao et al. · 1 citation

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