Because BaP may not fully account for the toxicity of all PAHs, this study provides relevant quantitative benchmarks for intestinal toxicity, advancing knowledge on current PAH exposure risk assessment.
Nedrick T. Distor, Manas Warke, Preethi H. Gunaratne et al.· Food and Chemical Toxicology· 0 citations
BACKGROUND
Gut dysbiosis, disrupted intestinal barrier integrity, and elevated bacterial lipopolysaccharide levels are hallmarks of obesity-related metabolic dysfunctions. Fish oil (FO) and tart cherry (TC) have individually been shown to modulate gut microbiota dysbiosis and improve gut integrity.
OBJECTIVE
We hypot...
Maryam Seifishahpar, Jung Han Kim, Mostafa Abdelrahman et al.· Journal of NutriLife· 0 citations
Opioid use disorder (OUD) disrupts hypothalamic stress signaling, yet the molecular state of human paraventricular nucleus (PVN) corticotropin-releasing hormone (CRH) neurons remains poorly defined. Using single-nucleus RNA sequencing of 343,819 human hypothalamic nuclei, we applied complementary human HYPOMAP/MapMyCel...
Lorna Barrall, Phillip Urbanczyk, Bruno Kluwe-Schiavon et al.· bioRxiv· 0 citations
Overall immune-cell composition was largely preserved despite differences in immune-cell distribution, spatial organization, and T cell clonality, and multi-cohort validation across complementary spatial and single-cell platforms identified consistent alterations in innate-adaptive immune organization in immunosuppress...
Shorook Naara, V. Kochat, Xiayu Rao et al.· Cell· 1 citation
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