Author

Ping-Zhao Hu

3 papers indexed here

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Open access Oct 2026

Combination of Radiation Treatment and PLK4-Inhibitor, CFI-400945, Leads to Upregulation of ICAM-1, STAT3 Activation, and Cellular Senescence in TNBC

Triple-negative breast cancer (TNBC) is one of the most aggressive and highly metastatic subtypes of breast cancer. It lacks canonical biomarkers and is often resistant to treatments, including radiotherapy (RT). This mandates the development of better treatments through identifying novel therapeutic targets and bi...

Isabel Kannampuzha, Vasudeva Bhat, Sugitha Janarthanan et al. · Breast Cancer: Basic and Cli... · 0 citations

Open access Sep 2026

Exploratory Transcriptomic Profiling of Triple-Negative Breast Cancer Patient-Derived Organoids Following Treatment with Radiation Alone and in Combination with Polo-like Kinase 4 Inhibition

Identification of novel biomarkers in triple-negative breast cancer (TNBC), one of the most aggressive breast cancer subtypes, is of critical clinical importance. Although radiation treatment (RT) is a cornerstone of TNBC treatment, resistance to RT compromises its therapeutic efficacy. Combining RT with radiosensitizi...

Sugitha Janarthanan, Isabel Kannampuzha, Harjot Athwal et al. · Radiation · 0 citations

#graph neural networks Open access Sep 2026

Spatially guided translation from histology images to transcriptomic profiles using foundation model-driven contrastive learning

Spatial transcriptomics (ST) enhances single-cell RNA sequencing by revealing transcript distribution, offering critical insights into heterogeneous diseases such as breast cancer. However, the high cost and lengthy processes of generating high-quality ST data limit clinical application. Recent deep learning methods pr...

Zi-Huai Huang, Zi-Yang Xu, Ping-Zhao Hu · PLoS Computational Biology · 0 citations