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Brainstem gliomas, particularly H3K27M-mutant diffuse midline gliomas (DMGs), lack effective therapies owing to anatomic inaccessibility, intact blood-brain barrier, and treatment resistance. Conventional models have low establishment rates and fail to preserve the native tumor microenvironment, limiting translational...
Intacranial TX103 infusion demonstrated acceptable safety and encouraging efficacy in rGBM, supporting a future phase 2 evaluation at the RP2D, and Cerebrospinal fluid showed a marked increase in CAR copy numbers and cytokine release, with minimal peripheral activity and no cumulative toxicity after repeated infusions.
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