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N. López-Bigas

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Open access Aug 2026

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis, divides lung NETs into grade-1 typical, and grade-...

A. Sexton-Oates, É. Mathian, N. Candeli et al. · 1 citation
#gene editing Open access Sep 2026

CRISPR-enhanced assessment of variants of unknown significance nominates oncology therapeutic targets and drug repositioning opportunities

CRISPR-VUS combines dependency-based rare-variant discovery with evidence-guided prioritisation to nominate candidate drivers, therapeutic targets and drug-repositioning hypotheses to nominate candidate drivers, therapeutic targets and drug-repositioning hypotheses.

A. Savino, Athanasios Oikonomou, Francesca Perrone et al. · 0 citations

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