Redirecting full-length FLT1 expression towards its soluble isoform by targeting alternative polyadenylation promotes postischaemic angiogenesis.
Using this mouse model, it is demonstrated that sFLT1 alone is sufficient for developmental vasculogenesis, whereas the specific loss of flFLT1 enhances reparative revascularization and angiogenesis and improves cardiac recovery after myocardial infarction.
M. Bundalo, Sandra Vorlová, Jessica Ulrich et al.
· Cardiovascular Research · 0 citations