Nimra Shahzad

In Silico Design and Evaluation of a CRISPR dCas9 DNMT3A DNMT3L Epigenetic Editing System Targeting the CDKN2A Promoter

CDKN2A (p16) is a tumor suppressor gene whose normal function is to stop the cell cycle from over dividing, allowing cells to enter senescence after completing their function. When the CDKN2A promoter is methylated, the gene is silenced, and cells continue dividing rather than stopping, a mechanism shown in published r...