Nathaniel Hess

Biomolecular Condensates Dictate the Folding Landscape of Protein Alpha-Helices

This work investigates how protein folding landscapes are altered inside condensates, using the protein α-helix as a model folded domain and develops a chemically specific, residue-resolution model for quantification of α-helical folding and applies it to characterize diverse helices within condensates of varying physicochemical properties.