Olezarsen reduced triglycerides across the hypertriglyceridemia spectrum, with greater effects in patients on background fibrates, particularly with diabetes, to support potential complementary mechanisms and further investigation of concomitant triglyceride-reducing therapy.
Annabel Z. Wang, V. Alexander, T. Prohaska et al.· Journal of Clinical Lipidolo...· 1 citation
Beyond arterial lipid deposition, TRL and Lp(a) converge on inflammatory and vascular remodeling pathways that, under the assumptions of observational mediation analysis, may explain their excess per-particle atherogenicity compared with LDL.
J. Morze, E. Björnson, Michael Y. Mi et al.· European Heart Journal· 0 citations
Modulation of the Angiopoietin-like protein 3–4–8–8 axis is a novel strategy to address residual atherosclerotic risk beyond traditional LDL receptor–dependent therapies.
I. C. Bitencourt, Andre Zimerman, N. Marston· Current Atherosclerosis Repo...· 0 citations
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