Genetic background determines allele-specific Pfkelch13-mediated artemisinin tolerance and persistence in Plasmodium falciparum
Findings reveal that a parasite’s genetic background acts as a strict evolutionary filter, uncoupling short-term tolerance from long-term persistence and establishing that genomic context determines allele-specific resistance trajectories.
Imran Ullah, Morgan C. Martin, Daouda Ndiaye et al.
· bioRxiv · 0 citations