Design, synthesis and anti-proliferative evaluation of novel pyrazole-based ar-turmerone derivatives in colorectal cancer cells
The rational design and synthesis of eight newly developed pyrazole-based compounds derived from ar-turmerone aimed at enhancing COX-2 inhibition and antiproliferative activity against CRC highlight the potential of pyrazole-based ar-turmerone analogs as promising lead candidates for selective COX-2 inhibition and targ...