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Author

Mohammad Shahrooei

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Open access Sep 2026

ER proteostasis failure in HYOU1 deficiency alters B cells, neutrophils, and interferon signalling

Multi-omics characterization of 2 patients with biallelic HYOU1 variants reveals that HYOU1 deficiency impairs the unfolded protein response, disrupts early B cell development, and alters neutrophil granulation as well as IFN signalling, further establishing ER proteostasis as a contributor to human immune homeostasis.

Aida Idani, S. Bibi-Triki, Tristan Stemmelen et al. · 0 citations
Open access Oct 2026

Biallelic loss-of-function PTPN6 variants lead to inflammatory lung disease and hemolytic anemia

Moussavi-Harami et al. report that biallelic loss-of-function variants in PTPN6, encoding the immune-regulatory phosphatase SHP1, cause anemia and fatal lung hyperinflammation in families from diverse ethnic backgrounds.

S. Moussavi-Harami, M. Zinter, M. Motta et al. · 0 citations
Aug 2026

A halotolerant strain of Bacillus cereus effectively regulates salt stress-responsive genes in Zea mays L. seedlings under stress condition.

Findings indicate that B. cereus isolate 74 enhances maize salt tolerance through coordinated regulation of antioxidant defense systems and metabolic reprogramming, which provides novel insights into PGPR-mediated stress adaptation.

Maryam Zakavi, Hossein Askari, Mohammad Shahrooei · 0 citations

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