Rapamycin rescues neuronal hyperexcitability and seizures driven by megalencephaly-causing AKT3 activation
The consistent therapeutic effects of mTOR inhibition across both systems support downstream targeting of the phosphoinositide 3-kinase–AKT–mTOR pathway as a rational therapeutic strategy for AKT3 -related epilepsy.
Yosuke Miyamoto, Takuma Mori, Mitsuru Ishikawa et al.
· Orphanet Journal of Rare Dis... · 0 citations