l-Malic acid is an important C4 platform chemical, but its direct production from raw lignocellulosic biomass by consolidated bioprocessing (CBP) remains constrained by biomass recalcitrance. Here, we developed an integrated lignin-side and sugar-side engineering strategy in the thermophilic fungus Myceliophthora therm...
Yu-Ying Zhang, Yu-Han Zhang, Li-Kun Han et al.· Synthetic and Systems Biotec...· 0 citations
The engineered strain achieved a marked increase in 1,4-butanediamine production, demonstrating that promoter editing via ABE can effectively regulate metabolic flux and enhance the production of the target product, as well as serving as a valuable reference for the biosynthesis of other high-value-added chemicals.
Yan-Ling Sun, Dicheva Ma, Ke Zhao et al.· Microorganisms· 0 citations
1,4-Butanediamine is an important raw material for the synthesis of engineering plastics such as Polyamide 46 with excellent performance, which is widely used in automotive, electronics and machinery manufacturing industries. In this study, Escherichia coli BL21(DE3) was used as the starting strain to systematically mo...
Xiangxiang Sun, Zongda Li, Yan-Ling Sun et al.· Journal of Genetic Engineeri...· 0 citations
A transfer learning-based predictor for acidophilic and alkalophilic proteins, trained on a curated non-redundant dataset, and an integrated pipeline for mining and engineering alkalophilic and thermophilic enzymes, combining sequence-based prediction, generative modeling, and multi-parameter virtual screening are deve...
Ruohan Zhang, Yiyang Zhang, Zhonghao Deng et al.· Bioresource Technology· 0 citations
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