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#gene editing Review Open access Oct 2026

Conditional genetic manipulation systems in mosquitoes: Progress, Challenges, and perspectives.

This review systematically summarizes the major types, regulatory mechanisms, and current advances of CGMSs in mosquitoes, with particular emphasis on different regulatory elements and their applications in functional gene analysis, studies of pathogen transmission mechanisms, and vector control strategies.

Jin Ma, Xin-Yi Bai, Xia Ling et al. · 0 citations
Open access Sep 2026

The sex determination gene doublesex is essential for female-specific flight and hearing properties in Aedes aegypti mosquitoes

The acoustic communication system supporting reproduction in disease-transmitting mosquitoes is sexually dimorphic, from the sounds that mosquitoes make to the properties of their flagellar ears. The molecular mechanisms shaping these dimorphisms, however, remain unclear. Here, we explored the contributions of the fema...

YuMin M. Loh, WenWei Loh, Jia Xin Yap et al. · 0 citations
Open access Sep 2026

Split suppression gene drives reveal a design tradeoff between inheritance and reproductive load in Aedes aegypti

Mosquito-borne pathogens cause approximately 700,000 deaths annually, highlighting the need for effective and sustainable vector control strategies. CRISPR-based gene drives offer a potential approach for suppressing disease-vector populations, but autonomous drives may spread beyond intended populations. Split gene dr...

William A. C. Gendron, Andrea L. Smidler, Ming Li et al. · 0 citations

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