Prime editing enables high-throughput identification and characterization of selective MutSβ inhibitors
DNA mismatch repair (MMR) maintains genome stability but paradoxically drives expansion of pathogenic repeats responsible for trinucleotide repeat disorders. Attenuating repeat instability through targeted inhibition of MMR is therefore a therapeutic strategy of interest; however, progress is constrained by a lack of r...
Yangwode Jing, Jun Yan, Denny Yang et al.
· bioRxiv · 0 citations