Functional divergence of TLR5 paralogs reveals distinct roles for TLR5M and TLR5S in salmonid Immunity.
Sensing of pathogen-associated molecular patterns (PAMPs) is a critical step in mounting effective immune responses against invading pathogens. Toll-like receptor 5 (TLR5) is central to this process through its recognition of bacterial flagellin. While the function of the canonical membrane-bound form (TLR5M) appears c...