Mau-Ho-Ang Chu

Multi-tiered in silico evaluation identifies Sarsasapogenin as a promising ERα-targeted phytochemical against breast cancer.

Predicted phase-I hydroxylation does not abolish ERα engagement, which argues for evaluating biotransformation products alongside the parent compound in computational screening of plant sapogenins.

Mechanistic insights into daidzin from Glycine max against breast cancer via network pharmacology and multi-level molecular modeling

An integrated in silico strategy combining network pharmacology and molecular modeling is used to prioritize daidzin targets and validate key interactions, with sirtinol as a reference compound, and prioritize a daidzin-MMP9 axis for experimental validation.

A novel DREB transcription factor enhances salt tolerance in peanut (Arachis hypogaea L.) through upregulation of AhP5CR and AhBADH, leading to increased osmolyte accumulation