Open access
Aug 2026
Subphenotypes of Sickle Cell Disease: A Guide to Targeting Treatment?
The pathophysiology of sickle cell disease, a phenotype caused by several common and many rarer genotypes, flows “down-stream” from the initiating event of sickle hemoglobin (HbS) polymerization [1]. Twenty years ago, building on prior observations
Martin H. Steinberg
· American journal of hematolo... · 0 citations