Author

Markus Hafner

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#gene editing Open access Oct 2026

MATRIN3 deficiency in human cells triggers an autoinflammatory response via cGAS-STING activation.

MATRIN3 (MATR3) is a broadly expressed nuclear RNA-binding protein. However, the mechanisms by which MATR3 maintains human cellular health remain poorly understood. In this study, we employed gene editing to model MATR3 deficiency in human induced pluripotent stem cells (iPSCs) and the HAP1 haploid cell line. To invest...

Zohirul Islam, A. Polash, Colin L. Sweeney et al. · Proceedings of the National... · 0 citations

Open access Oct 2026

DND1-NANOS3 shapes the PGC transcriptome via a heptanucleotide sequence in mRNA 3' UTRs.

Primordial germ-cell survival requires joint function of the RNA-binding proteins (RBPs) DND1 and NANOS3, yet how they collaborate has not been established. Here, we discover a paradigm of "two-factor authorization," where RBPs with low (DND1) or no (NANOS3) sequence specificity jointly repress RNAs via a unique high-i...

Masataka Suzawa, Chen Qiu, A. Polash et al. · Molecules and Cells · 0 citations