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Author

Maria Viskadourou

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#gene editing Open access Sep 2026

Boosting Ligand-Mediated Hepatic mRNA Delivery and Gene Editing Through Coordinated Pairing of Polyethylene Glycol-Modified Lipids

It is discovered that incorporating TriGalNAc-lipid into LNPs containing DSPE-PEG350 increased hepatic luciferase expression 4–6-fold over TriGalNAc-conjugated or unconjugated DMG-PEG2000 LNPs, and 60-fold over TriGalNAc-conjugated or unconjugated DSPE-PEG2000 LNPs in vivo.

Saed Abbasi, Kimberly Bockley, Johannes Dohr et al. · 0 citations
Jul 2026

Genome Editing in Primary Mammalian Cells via Electroporation of Editor RNA.

CRISPR editors including nucleases, base editors, and prime editors can efficiently correct disease-causing genetic variants or disrupt target genes. Editing outcomes are commonly evaluated in cultured primary cells, patient-derived cells, or engineered cell lines to study the impact of genetic variation or as a first...

Maria Viskadourou, J. Workman, Emma V Burke et al. · 0 citations

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