Author

M. Otto

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Open access Oct 2026

Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer’s disease from amyotrophic lateral sclerosis

Blood phosphorylated tau 217 (p-tau217) accurately detects Alzheimer’s disease (AD) pathology but is also elevated in amyotrophic lateral sclerosis (ALS), likely reflecting peripheral (big) tau released from muscle. Assays selectively measuring brain-derived (BD-) tau and BD-p-tau217 are therefore needed. We analysed s...

S. Abu-Rumeileh, H. Großkopf, Arthur Guthknecht et al. · Nature Communications · 0 citations

Open access Aug 2026

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

Potential causes of breakthrough ischemic stroke are identifiable in about half of breakthrough strokes and are associated with higher risk of recurrence compared with those without, warranting individualized approaches.

Federico De Santis, Matteo Foschi, Francesca Gabriele et al. · Journal of Neurology · 0 citations

Open access Jul 2026

Longitudinal trajectories of neurodegenerative biomarkers in the blood of patients with chronic heart failure

Serial biomarker assessment provided stronger prognostic information than baseline measurements alone in clinically stable patients with chronic HF, and longitudinal increases in circulating amyloid-β peptides associated with cognitive decline, structural brain changes, and mortality.

J. Traub, Anna Frey, G. Homola et al. · ESC Heart Failure · 0 citations