Background Loss of function mutations in the lipid transporter ABCA7 have been linked to increased risk for late onset Alzheimer’s disease (AD). Although rare and common variants in ABCA7 associated with AD alter the coding sequence and are predicted to impair protein function, the precise cell-type consequences of ABC...
Sarah E. Heuer, Fasiha Ahsan, Gizem Terzioglu et al.· bioRxiv· 0 citations
Diabetic kidney disease (DKD) is one of the main causes of kidney failure worldwide. Interestingly, patients affected by DKD are characterised by a low abundance of gut bacteria producing short fatty acids including butyrate, which is suggested to play a role in the decline of renal function. Consequently, we aimed to...
M. Nicese, A. Koudijs, Reshma A. Lalai et al.· Diabetes, obesity and metabo...· 0 citations
In vivo FLAP antagonism ameliorates disease severity and spinal cord inflammatory gene expression in the experimental autoimmune encephalomyelitis model, an animal model of MS, in both a prophylactic and therapeutic settings.
J. Konings, Fleur Mingneau, Serhii Chornyi et al.· Acta Neuropathologica· 0 citations
These findings support a model in which human astrocytes retain a form of ‘injury memory’ through sustained phenotypic and lipid metabolic remodelling, and identify PKC signalling as a tractable target for limiting the long-term consequences of rmTBI.
Luise Schlotterose, M. Struwe, A. Scheidig et al.· Cell Death & Disease· 0 citations
This study chemically synthesized two hitherto undescribed biosynthetic intermediates that were predicted based on bioinformatic analyses, CDP-threonine and CDP-N-methylthreonine, and showed that they are involved in the Type A PGM biosynthesis, as evidenced by mass spectrometric analyses of extracts of a set of C. dif...
P. Hensbergen, Bob van Puffelen, Nina Musch et al.· Proceedings of the National...· 0 citations
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