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Open access Aug 2026

Integrated Analysis of Skeletal Muscle Transcriptional Networks Characterizes Dysregulation in Pathways and Trait-Associated Regulatory Regions in Type 2 Diabetes

Together, the results reveal dysregulation in pathways in muscle tissue from individuals with diabetes, identify candidate drivers, and connect the genomic drivers of this dysregulation across type 2 diabetes and related metabolic traits.

A. Maddox, Nandini Manickam, Peter Orchard et al. · 0 citations
#gene editing Open access Sep 2026

In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson‐Gilford Progeria Syndrome

In vivo delivery of a locus‐specific DNA base editor to bone tissue is demonstrated, the timing of treatment required for maximum efficacy is delineated, and it is suggested that this system might be tailored for application to other monogenic bone disorders.

Wayne A. Cabral, Caleb M. Grenko, Diana Yeritsyan et al. · 0 citations

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