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Sex differences in genome-wide genetic overlap were not consistently reflected in PRS or MR, indicating that shared genetic architecture does not necessarily translate into sex-specific inherited liability or causal effects.
CIT-Lasso, a framework that uses only summary statistics to identify, genome-wide, sets of variants carrying non-redundant information on a phenotype, distinguishing likely causal variants from correlated variants that are merely associated, outperforms existing methods in false discovery rate control, power, and fine-...
This paper extensively evaluate a simple and effective analytical strategy that integrates GhostKnockoffs and state‐of‐the‐art marginal association tests that is robust to arbitrary relatedness structure and extends GhostKnockoffs to other GWASs settings.
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