Author

Lianlin Zeng

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Review Open access Sep 2026

Paradigm shift in macrophage polarization in osteoarthritis: from M1/M2 imbalance to macrophage state reprogramming in the ageing immune microenvironment

Osteoarthritis (OA) is one of the most common degenerative joint diseases, and its initiation and progression are closely associated with the inflammatory microenvironment within the joint. As key effector cells of innate immunity in the joint, macrophages contribute to synovial inflammation, cartilage matrix degradati...

Bandianzhuoma, Shi-Bin Yang, Jian-Jiao Mou et al. · Frontiers in Immunology · 0 citations

#gene editing Review Open access Aug 2026

Inflammaging and immunosenescence-driven remodeling of the immune microenvironment in osteoarthritis: mechanisms, immune regulation and immune reprogramming

It is highlighted that future OA treatment may gradually shift from symptom-oriented management toward disease-modifying therapy based on the identification of immune endotypes, and further studies are required to validate the underlying molecular mechanisms, evaluate safety, and conduct clinical trials, thereby facili...

Tong Wang, Wei Jiang, Xing-Xu Chen et al. · Frontiers in Immunology · 2 citations