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CAR-T cell therapy for autoimmune diseases: from immune suppression to immune resetting.
A review of immunopathogenesis and therapeutic gaps in representative autoimmune diseases, compares CAR-T applications in malignancies and autoimmunity, and evaluates emerging response endpoints, target-selection strategies, and safety considerations in autoimmune settings suggests CAR-T therapy offers a potential stra...
Universal CAR-T cell therapy: mechanisms and evasion strategies of bidirectional immune rejection.
This review systematically delineates the mechanisms underlying bidirectional immune rejection and comprehensively summarizes state-of-the-art mitigation strategies and highlights the development of alternative, inherently hypoimmunogenic cell sources as a fundamental approach to circumventing these immunological barri...