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Lei Xu

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#diffusion models Open access Sep 2026

scLDM: a conditional diffusion framework for single-cell perturbation prediction

Overall, scLDM provides a robust and biologically consistent strategy for in silico perturbation screening, and exhibits strong interpretability, as the learned perturbation embeddings show high functional alignment with known biological mechanisms.

Bo-Yang Wu, Yu-Hang Liu, Yue Cheng et al. · 0 citations
Sep 2026

Deciphering T-cell receptor-antigen recognition through interpretable residue-level interaction modeling.

Evaluation across multiple settings indicates that TCR-IFNet achieves competitive performance compared with existing methods, with higher AUPRC observed on both antigen-specific and healthy-sourced datasets, as well as improved results on independent test sets.

Wen-Yu Xi, Ru-Heng Wang, Xiu-Cai Ye et al. · 0 citations

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