Laura K. M. Han

Associations between immuno-metabolic markers, working memory, and functional brain activation in depressive and anxiety disorders

Background Cognitive impairment and immuno-metabolic dysregulation are commonly observed in depressive and anxiety disorders, but underlying brain processes remain unclear. This study examined relationships between immuno-metabolic markers, working memory performance, and task-related functional brain activation in per...

Six-year clinical course of depressive and anxiety disorders: analysis by age

Background Evidence on the association between age and the long-term course of affective disorders remains mixed. Objective This study examined the 6-year symptom and diagnostic trajectories of depression and anxiety in relation to age, and assessed whether social, lifestyle, somatic and clinical factors explained obse...

Global Structural Brain-Age in Adolescence: Application of an Established Method to Short-Interval, Longitudinal Data

Brain-age estimates from grey matter structure provide a promising tool to examine the neurobiology of mental health. However, whether existing models generalise to longitudinal adolescent data remains unclear. The CentileBrain Global-BrainAGE ‘Lifespan’ Model, was applied to N=138 participants (74 females, 64 males) f...

Adolescent brain-age differences between profiles based on suicidal ideation, distress and wellbeing

Determinants of the plasma metabolome: cross-sectional and longitudinal associations over six years in the NESDA cohort

This study provides hierarchical insights into the cross-sectional and longitudinal implications of health, stress, and lifestyle exposures for the plasma metabolome in the Netherlands Study of Depression and Anxiety.