GeoNicheTrans: Spatial Niche Inference and Immune Architecture Characterization in Oral and Oropharyngeal Squamous Cell Carcinoma Validated by CODEX Protein Profiling
Background: The tumor microenvironment is spatially organized into distinct ecological niches that shape immune responses and therapeutic outcomes, yet inferring spatial niches from transcriptomic data and validating them at the protein level remains challenging, particularly in oral and oropharyngeal squamous cell car...