Author

L. Mignani

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#gene editing Open access Oct 2026

Impact of Sphingolipid Metabolizing Enzyme β-Galactosylceramidase on Mitochondrial Sphingolipid Profile and Energetic Metabolism in Human Melanoma Cells

Background/Objectives: Mitochondrial plasticity, reflected by the capacity of cancer cells to shift between oxidative phosphorylation and glycolytic metabolism in response to genetic alterations and changes in the tumor microenvironment, represents a key feature of melanoma progression. Sphingolipids contribute to the...

Davide Capoferri, L. Mignani, M. Corli et al. · Lipidology · 0 citations

Open access Aug 2026

Impact of the sphingolipid metabolizing enzyme β-galactosylceramidase on mitochondrial sphingolipid profile and energetic metabolism in human melanoma cells

Targeted analysis of the mitochondrial sphingolipid profile, transcriptomic data, and mitochondrial structural and functional studies indicate that GALC KO leads to a sphin-golipid-driven mitochondrial metabolic suppression and may provide novel information for the development of efficacious approaches in mitochondrial...

Davide Capoferri, L. Mignani, M. Corli et al. · bioRxiv · 0 citations