Author

Leon Hetzel

2 papers indexed here

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Open access Sep 2026

Designing antimicrobials with programmable mechanism and safety

OmegAMP, a conditional diffusion framework controlling net charge, mean hydrophobicity, and sequence length, supporting de novo, analog, and motif-guided design, opens a programmable route to new peptide antibiotics whose mechanism and safety follow from the chosen prototype.

Paulina Szymczak, Marcelo Der Torossian Torres, Diogo Soares et al. · bioRxiv · 0 citations

#gene editing Open access Sep 2026

Creating bottom-up RNA transfer vehicles from synthetic protein assemblies.

This work demonstrates how proteins created by generative artificial intelligence can be harnessed for the rational engineering of RNA transport systems with the desired properties by overcoming the limitations of natural protein diversity.

Maren Kirstin Schuhmacher, Christoph Gruber, Christopher M. R. Lang et al. · Nature · 1 citation