Author

Kyungho Choi

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Jul 2026

KRAS Mutations Reprogram RNA m6A Modifications to Drive CD73-Dependent Immune Evasion in Colorectal Cancer.

It is found that KRAS mutations remodel the N6-methyladenosine (m6A) epitranscriptome to promote immune evasion and highlight METTL3 as a promising therapeutic target.

Seungjae Shin, Seung-Pyo Hong, Seoho Lee et al. · Cancer Research · 0 citations

#gene editing Open access Aug 2026

Precise genomic integration of large DNA fragments by donor-directed annealing using prime editing.

A programmable gene replacement tool, named prime assembly (PA), which adapts prime editors to produce one or two pairs of 3'-flaps on both the genome and donor DNA, allowing megabase-scale genomic excision and/or kilobase-scale donor insertion at the gene of interest.

Hojun Jung, Bada Jeong, Yong-Woo Kim et al. · Nature Biotechnology · 1 citation