13. DIRECT CRISPR-EDITING OF RS4702 DECIPHERS CELL-TYPE SPECIFIC EPISTATIC INTERACTIONS WITH SCHIZOPHRENIA POLYGENIC RISK
Background Schizophrenia (SCZ) has a complex, heterogeneous, and highly polygenic genetic architecture. Polygenic risk scores (PRS) assume additive genetic effects and may not capture epistatic or gene-by-environment interactions. However, PRS analyzed in conjunction with functional genomic approaches using CRISPR edit...
Kayla Retallick-Townsley, Kristina Rehbach, Carina Seah et al.
· European Neuropsychopharmaco... · 0 citations