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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

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Kristen Brennand

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#gene editing Open access Sep 2026

13. DIRECT CRISPR-EDITING OF RS4702 DECIPHERS CELL-TYPE SPECIFIC EPISTATIC INTERACTIONS WITH SCHIZOPHRENIA POLYGENIC RISK

Background Schizophrenia (SCZ) has a complex, heterogeneous, and highly polygenic genetic architecture. Polygenic risk scores (PRS) assume additive genetic effects and may not capture epistatic or gene-by-environment interactions. However, PRS analyzed in conjunction with functional genomic approaches using CRISPR edit...

Kayla Retallick-Townsley, Kristina Rehbach, Carina Seah et al. · 0 citations
#gene editing Open access Sep 2026

Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency

The results reveal a unique human mechanism of disease and offer therapeutic insight for this inflammasomopathy and CRISPR editing of human CD34+ hematopoietic stem and progenitor cells (HSPCs) led to very efficient and persistent gene deletion in vivo.

Tian-Li Xiao, J. R. Brewer, Maximillian J. Carlino et al. · 0 citations

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