Author

Kevser Kübra Kırboğa

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Open access Aug 2026

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron-binding ridge.

Frataxin is a mitochondrial iron-binding protein whose deficiency causes Friedreich's ataxia, yet the dynamic mechanisms by which this protein communicates iron-binding events to distal regions remain poorly understood. Traditional correlation-based analyses identify coupled residue motions but cannot resolve the direc...

Kevser Kübra Kırboğa, E. Küçüksille · The FEBS Journal · 0 citations

#graph neural networks Open access Aug 2026

Deep mutational scanning of CYP2C9, CYP2C19, and NUDT15 shows that pharmacogene variant interpretation requires assay-specific functional data.

This dimensionality dominates the data, and a supervised ESM-2 sequence baseline was benchmarked against the ESM1v zero-shot ensemble and AlphaMissense under position-based 5-fold cross-validation, together with three architectural extensions: AlphaFold structural features, multi-task learning across paired assays, and...

Kevser Kübra Kırboğa · G3 · 0 citations