#gene editing
Aug 2026
Engineering RNA-guided bridge recombinases for precise large-scale genome editing.
An RNA-guided bridge recombinase system is engineered through rational mutagenesis and AI-assisted directed evolution, enabling programmable chromosomal rearrangements in both plant and mammalian cells and achieving up to a 29.8-fold increase in activity.
Rui Gao, Jingjing Wei, Chao Sun et al.
· Trends in Biotechnology · 0 citations