The intracellular delivery of therapeutic biomacromolecules remains a fundamental challenge in modern drug development, primarily because the plasma membrane is inherently impermeable to large, hydrophilic molecules. While conventional small-molecule drugs also suffer from short circulation half-lives and off-target in...
P. Kavyashree, Rachel Anjous, K. Parang et al.· European journal of medicina...· 0 citations
Zinc oxide nanoparticles (ZnO-NPs) have emerged as promising inorganic nanocarriers for drug delivery due to their unique physicochemical properties, pH-responsive biodegradability, high surface area, and intrinsic biological activity. Their dissolution under acidic conditions enables controlled drug release within the...
A. Shirazi, Rajesh Vadlapatla, A. Koomer et al.· Materials· 0 citations
This review integrates the chemistry, the absorption, distribution, metabolism, elimination, and toxicity (ADMET) profile, and the full breadth of therapeutic applications of CuNPs within one framework and explicitly links the recently defined mechanism of cuproptosis to the rational design of next-generation multifunc...
K. Parang, Rajesh Vadlapatla, C. Charles et al.· Frontiers in Nanotechnology· 0 citations
Small interfering RNA (siRNA) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated Protein 9 (Cas9) complexes are effective approaches to temporarily downregulate protein expression via post-transcription RNA interference or permanently altering protein expression via editing gen...
Abdulelah Alhazza, Sorour Khayyatnejad Shoushtari, Hasan Uludağ et al.· Frontiers in Nanotechnology· 0 citations
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