Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia‐rel...
Rachel K. Morgan, Evelyn K. Matei, Junru Pan et al.· Alzheimer's & Dementia· 0 citations
Abstract BACKGROUND Farming populations may face a disproportionate share of adverse exposures influencing Alzheimer's disease (AD), yet farming data are rarely connected to cohorts with characterized AD neuropathology. Whether early‐life exposure is related to AD neuropathology is limited. METHOD Brain donors from two...
W. Powell, Eleanna M. Melcher, Rachel C. Otte et al.· Alzheimer's & Dementia· 0 citations
This work investigated associations of seven plasma essential trace elements, including manganese, iron, cobalt, copper, zinc, selenium, and molybdenum, with AD and all‐cause dementia risk.
Xin Wang, R. Albin, Bruno J. Giordani et al.· Alzheimer's & Dementia· 0 citations
Dementia is a public health challenge and exposures likely contribute to risk, though many have not been evaluated. We screened chemicals for enrichment with dementia genes and related pathways.
Scarlet Cockell, Sean M. Harris, Rachel K. Morgan et al.· Alzheimer's & Dementia· 0 citations
A high-resolution placental mQTL resource is constructed and systematically investigated how placental DNAm relates to early- and later-life traits, and to shared vulnerability and complex interactions among them.
A. Cilleros-Portet, Itziar González-Moro, Hachem Sadikki et al.· medRxiv· 0 citations
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