Aug 2026
In vivo genome-wide CRISPR screens of human T cells in solid tumours
Qi Liu, P. Chen, Esha Urs et al.
· Nature · 2 citations
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Aug 2026
Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function.
It is demonstrated that reconfiguring existing protein domains may uncover non-evolved genes that program therapeutically relevant cell states that program therapeutically relevant cell states.
Oliver Takacsi-Nagy, Sivakanthan Kasinathan, Austin Hartman et al.
· Cell · 0 citations
Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.
A virus-like particle (VLP)-based toolkit that delivers diverse CRISPR editing modalities to human monocytes, macrophages and dendritic cells with high efficiency while preserving viability and innate immune responsiveness is presented.
Hyuncheol Jung, Pascal Devant, Carter Ching et al.
· Nature Biotechnology · 0 citations