Visible-light-driven C2-phosphonylation of tryptophan in peptides and proteins
Tryptophan (Trp) residues are comparatively rare in proteins but are frequently positioned at sites that control folding, molecular recognition, ligand binding, and enzymatic activity. Direct chemical modification of Trp therefore offers a powerful strategy for perturbing protein structure and function. However, method...
Ranran Zhu, Xiaofei Gao, Xiaoying Lian et al.
· ChemRxiv · 0 citations