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John A. Calarco

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Open access Sep 2026

Spatiotemporal isoform profiling identifies a central activator of microexon splicing in C. elegans

The most comprehensive, tissue-resolved alternative splicing dataset in Caenorhabditis elegans to date is presented, spanning three major tissue types from early embryogenesis to adulthood, and broad developmental and tissue-regulated alternative splicing trends are uncovered and putative RNA-binding proteins are ident...

Bina Koterniak, Ernest Liang, Michael Zoberman et al. · 0 citations
Open access Aug 2026

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms

Deep long-read RNA sequencing and proteomics in induced pluripotent stem cell-derived cortical neurons is integrated to generate a high-resolution proteogenomic atlas of human neuron development, uncovering thousands of novel isoforms and revealing dynamic splicing changes in autism risk genes.

N. Xu, Katherine M. Rynard, E. Radley et al. · 1 citation

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