Author

Jiu-Xin Qu

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#gene editing Oct 2026

Programmable thermoregulation of the nuclease activity of LbCas12a.

CRISPR-Cas12a holds great promise for molecular diagnostics and gene editing due to its sequence-specific DNA recognition and robust trans-cleavage activity, yet precise tuning of its nuclease activity remains challenging. Herein, we report a simple temperature-regulation strategy using cost-effective ssDNA blockers, t...

Shi-Wen Tang, Xin-Yi Liao, Jun-Hong Chen et al. · Biosensors & bioelectronics · 0 citations

Open access Sep 2026

Harmonizing amplification and cleavage kinetics through crRNA scaffold mutation enables robust one-pot CRISPR-Cas12 diagnostics.

This work presents a broadly applicable one-pot detection strategy termed mutant scaffold-mediated RPA-CRISPR/Cas12a (MS-CRISPR), and introduces rationally designed point mutations into the crRNA scaffold to moderately attenuate Cas12a activation and cleavage kinetics.

Qing-Yang Jiang, Rui-Quan Xu, Zhi-Xin Lin et al. · Proceedings of the National... · 0 citations