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This work reveals YTHDC1 as a pivotal coordinator of the glucose‐glutamine‐cystine metabolic network and provides ATF4 mRNA nanomedicine‐based combination strategies to improve TNBC therapeutic efficacy.
The findings suggest that mRNab-LNPs offer a promising alternative to current therapies, providing a safer, more efficient approach to treating autoimmune diseases by resetting the humoral immune system.
A liver‐targeted lipopolymer nanoparticle‐mediated gene editing platform is developed to enable in vivo disruption of Mrg15 by co‐delivery of Cas9 mRNA and Mrg15 sgRNA to identify Mrg15 as a disease‐relevant epigenetic regulator in MASH and highlight liver‐directed P64H LPNP/CRISPR delivery as a promising non‐viral str...
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