Author

Jingwen Wei

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Open access Aug 2026

Esterified Cholesterol Conjugates Enable LNP-Mediated mRNA Delivery to the Blood-Brain Barrier Following Intravenous Administration.

This study presents a ligand-free lipid nanoparticle (LNP) platform that enables efficient mRNA delivery to the brain endothelium via systemic administration and establishes a new class of cholesterol-based lipids that provides a foundation for next-generation RNA therapeutics targeting BBB-associated diseases.

Ze-Ru Tian, Xu Wang, A. Benitez et al. · Advances in Materials · 0 citations

Aug 2026

Tunable polymers for polymer–lipid hybrid nanoparticles facilitate controlled organ-selective RNA delivery

This work advances chemical engineering strategies for RNA delivery by integrating materials design, molecular transport optimization and scalable nanoparticle synthesis, contributing to the broader development of biomolecular and polymer engineering solutions for therapeutic production and application.

Xu Wang, Ze-Ru Tian, Alexis Pacheco Benitez et al. · Nature Chemical Engineering · 0 citations