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Phytochemical investigation of the roots of Crepis napifera yielded six previously undescribed sesquiterpenoid derivatives, napifera A-F (1-5 and 16), together with 23 known compounds, which expand the known structural diversity of sesquiterpenoids from C. napifera.
Targeting dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) to regulate microglia-mediated neuroinflammation represents a promising therapeutic strategy for Alzheimer’s disease (AD). To address the limited brain penetration of our earlier lead ZJCK-6-46, an intramolecular cyclization strategy was...
Findings identify AT-11 as an early-stage chromeno[8,7-d]oxazole lead and extend the structure-activity basis for CDK16-directed inhibitor development.
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