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Jin-Xing Liu

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#gene editing Aug 2026

Engineering RNA-guided bridge recombinases for precise large-scale genome editing.

An RNA-guided bridge recombinase system is engineered through rational mutagenesis and AI-assisted directed evolution, enabling programmable chromosomal rearrangements in both plant and mammalian cells and achieving up to a 29.8-fold increase in activity.

Rui Gao, Jingjing Wei, Chao Sun et al. · 0 citations

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