Author

Jin-Jin Chen

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Open access Aug 2026

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

ABSTRACT Developing effective therapies for triple‐negative breast cancer (TNBC) requires the identification of key molecular regulators. Here, among the major m6A modulators, we find that only the reader YTHDC1 is specifically overexpressed in TNBC and correlates to unfavorable prognosis. Mechanistically, YTHDC1 orche...

Zheng-Hao Lai, Yi Wang, Na-Na Li et al. · Advancement of science · 0 citations

Jul 2026

Lipid Nanoparticle-Encapsulated mRNA-Targeting CD19 for B and Plasma Cell Depletion in Autoimmune Diseases 2308376

The findings suggest that mRNab-LNPs offer a promising alternative to current therapies, providing a safer, more efficient approach to treating autoimmune diseases by resetting the humoral immune system.

Yiming Zhou, Jinjin Chen, Chi-Peng Guo · Journal of Immunology · 0 citations

#gene editing Aug 2026

Lipopolymer Nanoparticle‐Mediated In Vivo CRISPR‐Cas9 Editing of Mrg15 Restores Mitochondrial Mitophagy to Alleviate Metabolic‐Associated Steatohepatitis

Metabolic‐associated steatohepatitis (MASH) remains difficult to treat due to the lack of interventions capable of targeting upstream disease drivers and achieving durable disease modification. The epigenetic regulator Mrg15 has been implicated in mitochondrial dysfunction and metabolic stress in the liver, suggesting...

Zixi Zhang, Jing Liao, Ting-Feng Yu et al. · Advanced Healthcare Material... · 0 citations