Author

Jian Zhang

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Review Open access Jul 2026

Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets

The models and drivers of tumor evolution are discussed, focusing on how cancer cells adapt and evolve under multidimensional selective pressure, including the intracellular, extracellular, and exogenous levels.

Kun-Yu Zhang, Xiu-Zhi Zhu, Yuxin Yan et al. · Signal Transduction and Targ... · 2 citations

Aug 2026

AKAP13 regulates GLI1/ULK1 axis and drive tumor resistance to next-generation HER2-targeted therapies.

It is reported that primary HER2-specific targeted therapy (tucatinib) resistant or sensitive breast cancers derived from clinical trial patients exhibited differential protein profiles and was proposed as a promising therapeutic strategy for HER2-positive breast cancer.

Qing Guo, Xinyu Chen, Linfeng Wu et al. · Oncogene · 0 citations